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KMID : 1134819980270010163
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Journal of the Korean Society of Food Science and Nutrition
1998 Volume.27 No. 1 p.163 ~ p.167
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Inhibition of Sarcoma - 180 Cell - induced Mouse Ascites Cancer by Astaxanthin - containing Egg Yolks
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Lee Sang-Ho
Park Cherl-Woo
Park Kyung-Ah
Lee young-Chun
Choi Eui-Sung
Ha Yeong-Lae
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Abstract
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Anticarcinogenic activity of astaxanthin-containing egg yolk(designate AEY) was investigated for mouse ascites carcinogenesis induced by mouse Sarcoma-180(S-180) cells. Female ICR mice(8 mice/treatment, 7~8 weeks of age, 25±1g) were injected, i.p. with S-180 cells(1×10^7cell/ml PBS). Two days later, each mouse was given 0.1ml PBS containing AEY(10, 25 or 50㎍/g body weight) or control egg yolk(CEY ; 50㎍/g body weight) every other day for 7 times. Control mice were only given 0.1ml S-180 cells and 0.1ml PBS. Mice treated with 25㎍/g body weight of AEY showed 24.8 days of life, which was equivalent to 138% of control mice’s life(18.0 days). Based on dose-dependant experiment of AEY, mice treated with 10㎍/g body weight showed slightly longer life(19.4 days) relative to mice treated with control mice, and mice treated with 50㎍/g body weight exhibited 21.9 days of life. Mice treated with any dose of AEY exhibited longer life than mice with CEY 50㎍/g body weight. Body weight of mice treated with AEY was reduced relative to that of control mice or CEY-treated mice. These results suggest that AEY inhibits the carcinogenesis of mouse ascites induced by S-180 cells.
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KEYWORD
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astaxanthin-containing egg yolk, Sarcoma-180, ascites carcinogenesis
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